in the course of time造句

1、In the course of time it told upon his temper.
一段时间以后，他的性情受到了影响。

2、In the course of time many empires have risen and fallen.
多少帝国兴衰事，全在时光流逝中。

3、It is possible that in the course of time a cure for cancer will be found.
治疗癌症的方法终有一天能找到。