bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Bad, a heterodimeric partner for Bcl-x L and Bcl-2, displaces bax and promotes cell death CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL Multiple Bcl-2 family members demonstrate selective dimerizations with Bax Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells Bax-independent inhibition of apoptosis by Bcl-XL Bcl-XL and Bcl-2 repress a common pathway of cell death. Expression of bcl-xL can confer a multidrug resistance phenotype. Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells
