Perforin-1 is a protein that in humans is encoded by the PRF1 gene.
Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
Functional significance of the perforin/granzyme cell death pathway.
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
Kagi, D. et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytoxicity. Science 265, 528-530
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mecha...
