Regulation of gene expression by SREBP and SCAP. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis. Sterols Regulate Cycling of SREBP Cleavage-Activating Protein (SCAP) between Endoplasmic Reticulum and Golgi Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-I, a membrane protein that facilitates retention o... Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention o... Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs.
