issue

issue, distribute, publish

这些动词均有“发行、发出、发给”之意。
issue: 多指通过官方或正式渠道正式发行。
distribute: 指把东西分发给所属者或应得者。
publish: 普通用词，多指出版发行文字作品，也指发布新闻或发表见解等。

issue, subject, theme, topic

这些名词均有“主题、话题”之意。
issue: 指有争论、议论，急需讨论研究的热点话题。
subject: 一般用词，使用广泛。指书籍、文章、演讲、讨论等所隐含的、暗示的，需要由读者或听众推断的主题或中心话题。
theme: 系正式用词，多指文学、艺术作品的主题，或论文、演说的主题。
topic: 普通用词，含义广泛，但其范畴小于subject。既可指文章、讲话的题目，谈话的内容，又可指提纲中的标题甚至段落的主题或中心思想。

problem, question, issue, matter

这些名词均含“问题”之意。
problem: 指客观上存在的、难以处理或难以理解的问题。
question: 通常指用口头或书面提出来要求回答或有待讨论解决的问题。
issue: 多指意见能达到一致的问题，但要通过争论或讨论解决。
matter: 含义不很具体，暗示人们考虑和关心的事和话题。

名词 issue:

1. an important question that is in dispute and must be settled
2. one of a series published periodically
   同义词：number
3. the act of providing an item for general use or for official purposes (usually in quantity)
   同义词：issuing, issuance
4. some situation or event that is thought about
   同义词：topic, subject, matter
5. supplies (as food or clothing or ammunition) issued by the government
   同义词：military issue, government issue
6. the immediate descendants of a person
   同义词：offspring, progeny
7. a phenomenon that follows and is caused by some previous phenomenon
   同义词：consequence, effect, outcome, result, event, upshot
8. the income or profit arising from such transactions as the sale of land or other property
   同义词：return, take, takings, proceeds, yield, payoff
9. the becoming visible
   同义词：emergence, egress
10. an opening that permits escape or release
    同义词：exit, outlet, way out
11. the act of issuing printed materials
    同义词：publication

动词 issue:

1. prepare and issue for public distribution or sale
   同义词：publish, bring out, put out, release
2. circulate or distribute or equip with
   同义词：supply
3. bring out an official document (such as a warrant)
4. come out of
   同义词：emerge, come out, come forth, go forth, egress
5. make out and issue
   同义词：write out, make out, cut

1. The government is trying to keep a low profile on this issue.
   政府力图在这个问题上保持低姿态。
2. The leadership of the movement are in agreement on this issue.
   这一运动的领导层对这个问题的看法一致。
3. The government adopted an uncompromising posture on the issue of independence.
   政府在独立的问题上采取了毫不妥协的态度。
4. Parliament will debate the nationalization issue next week.
   议会将在下周辩论国有化议题。
5. I bought the new stamp the day of its issue.
   这种新邮票是我在发行当天买到的。
6. Banknotes of this design were first issued 10 years ago.
   这种图案的钞票是十年前首次发行的。

is.sue

n.（名词）

The act or an instance of flowing, passing, or giving out.
流出，放出：流出、通过或放出的行为或状态
The act of circulating, distributing, or publishing by an office or official group:
发行，印行：某部或官方组织进行流通、分配或印刷出版的行为：
例句：
government issue of new bonds.
政府发行的新公债

Something produced, published, or offered, as:
出版，发行：生产、印刷或供给的物品，例如
An item or set of items, as stamps or coins, made available at one time by an office or bureau.
成套发行：一细目或一套细目，例如邮票和货币的发行，通常是由部或局在某一段时间内规定有效的
A single copy of a periodical:
期刊的单行本：
例句：
the March issue of the magazine.
这本期刊的第三期

A distinct set of copies of an edition of a book distinguished from others of that edition by variations in the printed matter.
特刊，特辑：一本书在印刷材料上不同于其它版本的一套特殊的版本
A final result or conclusion, as a solution to a problem.
结果，决议：最终结论或结果，如问题的解决办法
Proceeds from estates or fines.
利润，收益：从房地产或罚金中得到的收入
Something proceeding from a specified source:
结果，始末：从特殊的来源得到的东西：
例句：
suspicions that were the issue of a deranged mind.
被扰乱的情绪是疑心的根源

Offspring; progeny:
子孙后代，后嗣：
例句：
died without issue.
死时无子孙

A point or matter of discussion, debate, or dispute:
争议，辩论：争议、争论、争执的要点或事件：
例句：
legal and moral issues.
法律和道德的争议

A matter of public concern:
议题：公众关心的事物：
例句：
refused to address the economic issues.
拒绝对公众关心的经济问题发表言论

The essential point; crux:
重点，难题：必要的观点；难题：
例句：
the issue of how to provide adequate child care.
如何提供适当的儿童护理的难题

A culminating point leading to a decision:
结果，结论：需要决定的关键点：
例句：
bring a case to an issue.
把案子提到决议阶段

A place of egress; an outlet:
出口位置，宣泄口：
例句：
a lake with no issue to the sea.
没有通向海洋的出水口的湖泊

Pathology
【病理学】
A discharge, as of blood or pus.
排血，排脓：排出，例如血或脓
A lesion, a wound, or an ulcer producing such a discharge.
伤口，溃病：排脓或排血的损伤、伤口或溃疡
Archaic Termination; close.
【古语】 结束；终止
v.（动词）
is.sued,is.su.ing,is.sues
v.intr.（不及物动词）
To go or come out.See Synonyms at appear
出来，出现参见 appear
To accrue as proceeds or profit:
收益，生息：收入或利息增加：
例句：
Little money issued from the stocks.
股票获利很少

To be born or be descended.
诞生，传代
To be circulated or published.
发行，出版
To spring or proceed from a source.See Synonyms at stem
由…产生，源自参见 stem
To terminate or result.
结束，终止
v.tr.（及物动词）
To cause to flow out; emit.
使流出；排出
To circulate or distribute in an official capacity:
流通，发出：通过政府机关流通或分配：
例句：
issued uniforms to the players.
给演员发制服

To publish:
出版：
例句：
issued periodic statements.
出版定期声明书

<习惯用语>at issue
In question; in dispute:
待解决的；争议中的：
例句：
.Many people fail to grasp what is really at issue here.(Gail Sheehy)
.很多人都没有领会到这里到底在争论什么.(盖尔·希伊)

At variance; in disagreement.
有分歧的；不一致的
join issue
To enter into controversy.
参加争论
Law To submit an issue for decision.
【法律】 提交审议的议题
take issue
To take an opposing point of view; disagree.
对…持异议；不同意
来源：
Middle English
中古英语
from Old French eissue, issue
源自 古法语 eissue, issue
from Vulgar Latin *exôta
源自 俗拉丁语 *exôta
alteration of Latin exita [feminine past participle of] exore [to go out]
拉丁语 exita的变化 [] exore的阴性过去分词 [流出，出来]
ex- [ex-]
ex- [前缀.排.、.向外.]
ore [to go] * see ei-
ore [去] *参见 ei-

【引伸】
is.suer
n.（名词）
is.sueless
adj.（形容词）