hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Mammalian SIRT1 represses forkhead transcription factors. SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic gen... Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. I.—Records of the Geological Survey of India: General Report for 1907. By SirT. H. Holland K.C.I.E., D...
